Author(s): Troney Mckee*
This systematic review explores the intricate association between a genetic predisposition to vitamin D and the susceptibility to Non-Communicable Diseases (NCDs). By employing a comprehensive approach, we scrutinized the existing literature to identify and analyze studies investigating the genetic links between vitamin D metabolism and various NCDs. A genetic risk score was utilized as a measure to assess the collective impact of multiple genetic variants associated with vitamin D metabolism. Our findings reveal a nuanced and complex relationship, with certain genetic profiles demonstrating heightened susceptibility to specific NCDs. The identification of these genetic predispositions opens avenues for personalized medicine and targeted interventions to mitigate the risk of NCDs in genetically susceptible populations.
